On this page Jump to a section
- Key facts
- What the research says about cannabis and ED
- Why “linked to ED” is not the same as “causes ED”
- Heavy versus occasional use
- Smoking, tobacco and other factors
- Does weed help ED?
- Cannabis and ED pills: what the labels say
- What each path includes
- When to see a provider and safety checks
- If ED is the problem you want treated now
- Mendoxa plans and prices
- FAQ
- How we wrote this
- Sources and references
Key facts at a glance
- The pooled association
- ED prevalence was 69.1% versus 34.7% in the pooled study samples; these are not your personal odds of EDPizzol et al. 2019 meta-analysis · PMC
- Cause or link?
- A genetic analysis did not find evidence that cannabis use causes ED; it does not prove cannabis is risk-freeZhang et al. · Int J Impot Res (online 2024)
- ED pill labels
- No mention of cannabis or marijuana; sildenafil is contraindicated with organic nitratesViagra (sildenafil) label · DailyMed
- Compounded status
- The Mendoxa compounded tablet is not FDA-approvedFDA compounding Q&A
What the research says about cannabis and ED
The studies disagree, and they measure different things. Start with the design and population before applying a headline number to yourself.
| Study | Year | Design / population | Finding and limit | Source |
|---|---|---|---|---|
| Pizzol et al. | 2019 | Meta-analysis; 5 case-control studies, 3,395 men | ED prevalence: 69.1% in cannabis smokers versus 34.7% in controls; odds ratio (OR) 3.83 (95% CI 1.30–11.28). High heterogeneity (I² 90%); prediction interval crossed 1.00. Association, not proof of cause. | PubMed abstract |
| Zhang et al. | 2024 online; 2025 issue | Mendelian randomization; genetic data | No evidence of a causal relationship: cannabis use disorder OR 0.97 (95% CI 0.87–1.10); lifetime use OR 1.13 (95% CI 0.84–1.50). | PubMed abstract |
| Davis et al. | 2025 | TriNetX claims analysis; 29,442 per matched group for the short-term analysis | At 3 months–1 year, ED diagnoses were 0.9% versus 0.2% (RR 3.99 [3.05, 5.21]) with versus without cannabis abuse/dependence diagnoses. Diagnosis codes cannot establish a dose-response relationship. | PubMed abstract |
| Barbonetti et al. | 2024; online 2023 | Clinic cohort of men with sexual dysfunction | The 1–2 joints/week group had a better penile arterial response on testing than non-users and those using >2 joints/week. This finding is not a treatment trial. | PubMed abstract |
| Otieno et al. | 2026 | Cross-sectional online survey; 549 sexual minority men | Marijuana users had 1.83 times the odds of reporting ED (95% CI 1.23–2.74). Self-reported outcomes in a specific population; causation remains unresolved. | PubMed abstract |
| Smith et al. | 2010 | Telephone survey; 8,656 Australians | Daily use was associated with difficulty reaching orgasm as desired in men. An orgasm finding does not establish an ED effect. | PubMed abstract |
| Sun & Eisenberg | 2017 | US cross-sectional survey; 22,943 men | Weekly and daily use were associated with more frequent sex. Frequency is a different outcome from erection quality. | PubMed abstract |
Sources: published abstracts linked in each row. Study estimates are reproduced as published, without recalculation. Accessed Oct 22, 2026.
How to use this table: the pooled prevalence describes the included samples, not all US cannabis users. The claims study counts recorded diagnoses; the survey asks about self-reported ED. Those percentages answer different questions.
Why “linked to ED” is not the same as “causes ED”
An association means cannabis use and ED occurred together in a study; it does not establish that cannabis caused the erection problem. The meta-analysis itself called for longitudinal research and reported substantial differences between studies.
The genetic analysis did not find evidence of causation. The claims study found an association but could not assess dose and used diagnosis codes as proxies for use. Neither result settles what is happening for one person.
Keep the assessment broader than weed: NIDDK lists blood vessel disease, diabetes, hormone problems and anxiety among possible causes. Our erectile dysfunction guide explains what to discuss at a visit.
Heavy versus occasional use: what the studies separate
Most cannabis–ED studies do not split users by how much they use. The 2019 meta-analysis had no frequency or dose comparison and named a dose-response relationship as a question for future research (Pizzol et al.).
- 1–2 joints per week versus more than 2: in men evaluated for sexual dysfunction, the 1–2 joints/week group had significantly higher penile peak systolic velocity on Doppler than both non-users and men using more than 2 joints/week (Barbonetti et al.).
- Daily use: daily use, compared with none, was associated with orgasm difficulties in men, not with a measured erection outcome (Smith et al.).
- Abuse or dependence diagnosis: men with a cannabis abuse/dependence diagnosis had a higher risk of an ED diagnosis, at the short-term follow-up (Davis et al.).
There is no established “safe for erections” frequency in these abstracts. A joints-per-week category is not a measured THC dose, and a dependence diagnosis is not interchangeable with occasional use. Bring your actual pattern to the provider rather than choosing a cutoff from these studies.
Smoking, tobacco and other factors that travel with cannabis
The Pizzol meta-analysis covered men who smoked cannabis (Pizzol et al.). NIDDK lists smoking cigarettes, drinking too much alcohol, using recreational and illicit drugs and not getting enough physical activity among lifestyle behaviors that may contribute to ED.
These habits often overlap. In the andrology cohort, cannabis users reported higher alcohol and tobacco consumption than non-users (Barbonetti et al.). That overlap is one reason a cannabis association is hard to read on its own. If drinking is part of the picture, read ED and alcohol.
Does weed help ED?
Cannabis is not an FDA-approved ED treatment. FDA’s cannabis and CBD overview distinguishes cannabis from approved cannabinoid medicines, such as Epidiolex (cannabidiol) for certain seizure disorders. Those approvals do not cover ED.
More frequent sex does not establish better erections: that is the outcome distinction in Sun and Eisenberg’s survey. If nerves are your concern, read performance anxiety and ED; NIDDK identifies anxiety and stress as possible contributors.
Cannabis and ED pills: what the labels say
The sildenafil label, tadalafil label and apomorphine label do not name cannabis or marijuana. Their silence is not clearance to combine substances: disclose cannabis, CBD, alcohol and your full medicine list before a prescription decision.
| Label | Cannabis named? | What the label does list |
|---|---|---|
| Viagra (sildenafil) | No | Contraindicated with organic nitrates or nitrites and with riociguat; CYP3A4 inhibitors named in the label (ritonavir, ketoconazole, itraconazole, erythromycin) increase exposure (Viagra (sildenafil) label) |
| Cialis (tadalafil) | No | Contraindicated with any organic nitrate and with riociguat; named CYP3A4 inhibitors (ketoconazole, ritonavir) increase exposure; substantial alcohol (≥5 units) may lead to hypotension (Cialis (tadalafil) label) |
| APOKYN (apomorphine injection; Parkinson’s treatment) | No | Contraindicated with 5HT3 antagonists such as ondansetron; avoid alcohol; warns about sleepiness and asks about sedating medicines (APOKYN (apomorphine) label) |
Sources: Viagra (sildenafil) label; Cialis (tadalafil) label; APOKYN (apomorphine) label. Full-text label search, accessed Oct 22, 2026.
The CYP3A4 entries above identify interactions listed for those medicines; they do not establish a cannabis interaction. For the contraindicated nitrate combination, see ED pills and nitrates and the sildenafil label and tadalafil label.
What each path includes
You do not have to prove weed caused the problem before asking about ED care. Use these questions to prepare for a visit, not to decide which medicine to take yourself.
| Path | Question it addresses | What it includes | Boundary |
|---|---|---|---|
| Reviewing your cannabis pattern | When do erection problems occur? | Bring when erection problems began, how often you use cannabis, and whether tobacco or alcohol is involved; NIDDK lists these behaviors as possible contributors | The reviewed abstracts do not establish whether stopping restores erections |
| ED assessment | What else could be causing ED? | History, medicine review, examination and tests as indicated (NIDDK) | Cannabis use does not replace a check for vascular, diabetic or hormonal causes |
| Standalone ED prescription | Whether an ED medicine is suitable | Sildenafil or tadalafil if appropriate (Viagra (sildenafil) label; Cialis (tadalafil) label) | Both require sexual stimulation and are contraindicated with nitrates (sildenafil label; tadalafil label) |
| Mendoxa 3-in-1 visit | Whether the compounded tablet fits | Online review by Independent licensed providers; Prescription required; disclose cannabis use on the intake | Compounded drugs are not FDA-approved |
Sources: NIDDK causes; NIDDK diagnosis; Viagra (sildenafil) label; Cialis (tadalafil) label; FDA compounding Q&A; Mendoxa ED product information. Accessed Oct 22, 2026.
Compare ED medication options and read can ED be reversed? for questions about underlying causes.
Bring to the online intake: when the problem began; whether it happens with and without cannabis; the products and frequency you use; and your medicines, supplements, tobacco and alcohol use. Ask the provider whether you need an in-person assessment as well.
Could Mendoxa ED care fit you?
Online ED visit · Prescription required · Independent licensed providers · Not available in California
When to see a provider, and safety checks before ED medication
Book a visit if erection problems keep happening, appeared alongside heavier use, or come with other health changes. NIDDK describes a medical and sexual history, physical exam and selected tests. Be specific about cannabis, tobacco, alcohol and medicines.
- Sildenafil and tadalafil are contraindicated with organic nitrates or riociguat (Viagra (sildenafil) label; Cialis (tadalafil) label).
- An erection lasting more than 4 hours needs immediate medical care (Viagra (sildenafil) label; Cialis (tadalafil) label).
- Stop and seek care for sudden vision loss or sudden decrease or loss of hearing (Viagra (sildenafil) label; Cialis (tadalafil) label).
- Reported common adverse effects include headache and flushing with sildenafil, and headache, indigestion and back pain with tadalafil (Viagra (sildenafil) label; Cialis (tadalafil) label).
- The APOKYN (apomorphine) label contraindicates use with 5HT3 antagonists such as ondansetron and warns about nausea and fainting.
Give the prescriber your full medicine list, including anything you use recreationally. See sildenafil versus tadalafil for how the two standalone options differ.
If ED is the problem you want treated now
Start the Mendoxa online ED visit with the erection problem you want help with and an honest account of cannabis use. Independent licensed providers review suitability and decide whether the compounded tablet is appropriate. Prescription required.
The tablet combines sildenafil, tadalafil and apomorphine; it is not FDA-approved. Ingredient references are the Viagra (sildenafil) label, Cialis (tadalafil) label and APOKYN (apomorphine) label; APOKYN is an injectable Parkinson’s treatment, and its label is not approval of this ED combination.
For the format and ingredient discussion, read about the combination ED tablet. Compare the available quantities and totals in the single Mendoxa table below, then bring your questions to the visit.
Mendoxa ED plans and prices
The Mendoxa ED tablet is a compounded rapid-dissolve tablet with sildenafil (the active ingredient in Viagra), tadalafil (the active ingredient in Cialis) and apomorphine (APOKYN label). It dissolves under the tongue. A licensed clinician decides if it fits you and selects the strength. Compounded medicines are not FDA-approved.
| Tablets per month | 1-month total | Per tablet (1 month) | 3-month total | Per tablet (3 months) |
|---|---|---|---|---|
| 6 tablets / month | $129 | $21.50 | $329 | $18.28 |
| 10 tablets / month | $149 | $14.90 | $379 | $12.63 |
| 20 tablets / month | $179 | $8.95 | $449 | $7.48 |
The 3-month total covers three months at the monthly tablet quantity shown.
If prescribed · Cancel anytime · Available in 49 states (not California). Prices from the Mendoxa intake at try.mendoxa.co/f/ed on Oct 22, 2026. The intake always shows the current price.
FAQ
Can smoking weed every day cause erectile dysfunction?
It may be associated with problems, but daily use has not been established as a cause of ED. Smith et al. linked daily use to orgasm difficulties; Davis et al. studied abuse/dependence diagnoses rather than a daily-use threshold. These are different exposures and outcomes.
Does weed help ED or make you last longer?
Cannabis is not an FDA-approved ED treatment (FDA cannabis overview). A survey linked daily use with reaching orgasm both too quickly and too slowly, so it does not establish that weed reliably makes you last longer (Smith et al.).
Can I take Viagra or Cialis if I use weed?
The sildenafil label and tadalafil label do not mention cannabis or marijuana; that does not establish that the combination is safe for you. Both contraindicate nitrates. Disclose your cannabis use and all other substances so the prescriber can review suitability.
Will ED go away if I stop smoking weed?
The reviewed abstracts do not establish whether quitting reverses ED or how long recovery would take. NIDDK lists recreational drug use and cigarette smoking among possible contributors, but other causes still need consideration. Read can ED be reversed? and discuss your pattern at a visit.
Does CBD help erectile dysfunction?
CBD is not an FDA-approved ED treatment. FDA’s cannabidiol (CBD) overview describes approval of Epidiolex (cannabidiol) for certain seizure disorders; that approval does not establish a benefit for erections. Tell your provider about CBD products too.
Can I get ED treatment online if I use cannabis?
You can start a Mendoxa online visit and disclose cannabis use; it is not automatic approval for a prescription. Independent licensed providers assess suitability. Prescription required. The compounded tablet is not FDA-approved; ask whether an approved option or an in-person assessment would better meet your needs.
Ready to see if the Mendoxa ED tablet fits you?
From $129/month if prescribed · Cancel anytime · Available in 49 states (not California)
How we wrote this
Written by the Mendoxa editorial team · Sources: DailyMed/FDA. Medical facts on this page come from the FDA-approved labels on DailyMed and Drugs@FDA; each drug name links to its label. Cannabis findings come from published study abstracts, not the medicine labels; observational associations are kept separate from evidence about causation. We checked the linked sources on Oct 22, 2026, using full PubMed abstracts returned by search when direct pages blocked access, and retained only verified figures. Searches of the sildenafil label, tadalafil label and apomorphine label found neither cannabis nor marijuana; that absence does not establish safety when substances are combined.
Updated Oct 22, 2026. This page is general information, not medical advice. A licensed clinician decides what fits you.
References
- DailyMed: VIAGRA (sildenafil citrate) tablet, film coated, label revised 12/2017. Accessed Oct 22, 2026.
- DailyMed: CIALIS (tadalafil) tablet, film coated, label revised 3/2026. Accessed Oct 22, 2026.
- DailyMed: APOKYN (apomorphine hydrochloride) injection, label revised 6/2022. Accessed Oct 22, 2026.
- FDA (Drugs@FDA): VIAGRA (sildenafil) prescribing information, NDA 020895. Accessed Oct 22, 2026.
- FDA (Drugs@FDA): CIALIS (tadalafil) prescribing information, NDA 021368. Accessed Oct 22, 2026.
- FDA: Compounding and the FDA, questions and answers. Accessed Oct 22, 2026.
- Pizzol D, et al. Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis. Am J Mens Health, 2019. Accessed Oct 22, 2026.
- Zhang Y, et al. The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis. Int J Impot Res, 2024/2025. Accessed Oct 22, 2026.
- Davis R, et al. Association of cannabis abuse/dependence on risks of erectile dysfunction and testosterone deficiency. J Sex Med, 2025. Accessed Oct 22, 2026.
- Barbonetti A, et al. Is marijuana a foe of male sexuality? Andrology, 2024. Accessed Oct 22, 2026.
- Otieno M, et al. Marijuana use and erectile dysfunction in sexual minority men. J Cannabis Res, 2026. Accessed Oct 22, 2026.
- Smith AM, et al. Cannabis use and sexual health. J Sex Med, 2010. Accessed Oct 22, 2026.
- Sun AJ, Eisenberg ML. Marijuana use and sexual frequency in the United States. J Sex Med, 2017. Accessed Oct 22, 2026.
- FDA: Regulation of cannabis and cannabis-derived products, including CBD. Accessed Oct 22, 2026.
- NIDDK: symptoms and causes of ED. Accessed Oct 22, 2026.
- NIDDK: diagnosis of ED. Accessed Oct 22, 2026.
- Mendoxa ED care (product, format, max 1 dose per 24 hours). Accessed Oct 22, 2026.
- Mendoxa ED intake: plan prices (term_options). Accessed Oct 22, 2026.
About Mendoxa
Mendoxa (mendoxa.co) is a US telehealth brand. Independent licensed providers (licensed clinicians in the LocumTele network) review each online visit, and prescriptions are filled by Rush Pharmacy, a licensed US pharmacy. Available in 49 states (not California).
- Prescription required. A licensed clinician reviews every visit and can say no. A prescription is not automatic.
- A compounded medicine is not an FDA-approved finished product (FDA compounding Q&A).
- Plans: 1 month or 3 months, from $129. If prescribed · Cancel anytime · Available in 49 states (not California).
Compounded medication prescribed only if a licensed U.S. clinician decides it is appropriate. Not FDA-approved as a finished product. Not available in California. This site is not for emergencies. Call 911 if you need urgent care.