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Key facts at a glance
- Reversal depends on the cause
- Treating the underlying cause is the starting point when possible.NIH/NIDDK: ED treatment
- Lifestyle evidence has limits
- 17 of 55 men receiving intensive lifestyle advice reached the trial’s non-ED score, versus 3 of 55 controls, over 2 years.Esposito 2004: selected obese men
- Remission can happen
- 29% remission over 5 years in one Australian cohort; this does not establish that ED resolved without treatment.Martin 2014: observational study
- Mendoxa’s regulatory status
- The Mendoxa tablet is compounded and not FDA-approved.FDA: compounded drugs are not FDA-approved
Can ED be reversed? By cause
Use this table to prepare for a visit, not to diagnose yourself. NIDDK lists vascular, nerve, hormonal, medicine and emotional causes; more than one may need attention.
| Cause | Outlook | Evidence and limits | Next step |
|---|---|---|---|
| Lifestyle / vascular risk factors | Improvement is possible; the best trial here does not cover every vascular cause. | In 110 obese men aged 35–55, intensive weight-loss and activity advice led 17/55 to an IIEF score of at least 22 versus 3/55 controls after 2 years. Diabetes, hypertension and high cholesterol were excluded (Esposito 2004). | Discuss risk factors; use our lifestyle guide for practical changes. |
| Medication side effects | A prescriber-led change may help if a medicine contributes. | NIDDK recommends reviewing current medicines and considering a change when appropriate (NIDDK treatment). | Ask the prescriber before changing or stopping treatment; see lisinopril and ED. |
| Low testosterone | Sexual function may improve; improvement is not proof of permanent reversal. | A 1-year trial in 790 symptomatic men aged 65+ with low testosterone found a moderate sexual-function benefit from testosterone gel (ingredient information: testosterone label; study results: Snyder 2016). | Ask whether testing is appropriate; NIDDK describes a blood test and examination. |
| Anxiety / psychological causes | Counseling can address anxiety and stress about sex. | Counseling is an option when emotional issues affect ED (NIDDK counseling guidance). | Discuss the pattern with a clinician; read performance anxiety and ED. |
| Diabetes | Management may help; it is not a promise that existing damage will reverse. | Good diabetes management may prevent and treat ED associated with nerve and circulation problems (NIDDK diabetes guidance). | Coordinate diabetes and ED care; see ED and diabetes. |
| After prostate surgery | Recovery is possible, with substantial variation. | A 2009 analysis of 22 studies reported 58% erectile-function recovery after radical prostatectomy; included men had no pre-surgery ED and at least 1 year of follow-up (Tal 2009). | Ask your urologist what recovery means for your operation and follow-up. |
Sources: NIDDK, Esposito, Snyder, Tal. Accessed Oct 21, 2026.
Read the numbers carefully. The lifestyle trial measured an erectile-function score, while the surgical studies used recovery definitions that varied. Neither establishes a universal chance of permanent, unaided erections (Esposito; Tal).
Can ED go away on its own?
ED is not necessarily permanent: Martin’s 2014 cohort study reported 29% remission over 5 years in eligible men. But it was observational, not a trial of doing nothing; its abstract does not establish untreated recovery.
Treat that as a reason for hope, not a reason to postpone a visit. ED can signal another health problem (NIDDK). For symptoms and the broader evaluation, see our erectile dysfunction overview.
While you work on the cause, treatment can help now
You can ask about symptom treatment while pursuing the cause. Sildenafil’s label and tadalafil’s label describe ED treatment that requires sexual stimulation, not restoration of the underlying blood vessels, nerves or hormones.
For example, the Viagra (sildenafil) label reports improved erections in 57% of treated men versus 10% receiving placebo in a diabetes study, and 43% versus 15% among radical-prostatectomy patients across trials. Those are medication-response results, not reversal rates or evidence for Mendoxa’s compounded combination.
A Mendoxa visit lets you ask whether its ED option fits your history and current medicines. Prescription required · Independent licensed providers. Explore Mendoxa ED care or how an online ED prescription works.
What each path includes
Choose the next conversation by what you need answered. These paths can complement one another.
| Path | What it addresses | What to ask |
|---|---|---|
| Your usual clinician | Cause evaluation and review of current medicines (NIDDK overview). | “What could be contributing, and what needs checking?” |
| Counseling | Anxiety or stress about sex; a partner may be involved (NIDDK). | “How can we address the pressure around sex?” |
| Your urologist after surgery | A discussion grounded in your operation and recovery; published recovery estimates vary (Tal 2009). | “Are we measuring erections with treatment or without it?” |
| Mendoxa online visit | An assessment reviewed by independent licensed providers; prescription required. | “Is the compounded option appropriate for me while I address the cause?” |
Sources: NIDDK overview, NIDDK treatment and Tal 2009; Mendoxa intake for current service details. Accessed Oct 21, 2026.
Before a visit, write down when ED began, any medicine changes, relevant health conditions and what you want treatment to achieve. Bring that list to the clinician rather than trying to choose a cause from the table.
Could Mendoxa ED care fit you?
Online ED visit · Prescription required · Independent licensed providers · Not available in California
Safety before starting ED medication
- The Viagra (sildenafil) and Cialis (tadalafil) labels contraindicate use with organic nitrates in any form, or with a guanylate cyclase stimulator such as riociguat.
- The sildenafil label says to get emergency care for an erection that lasts more than 4 hours; the tadalafil label warns untreated priapism “can result in irreversible damage to the erectile tissue.”
- Stop and get care for a sudden loss of vision in one or both eyes, or a sudden decrease or loss of hearing (Viagra (sildenafil) label).
Share your complete medicine list with the prescriber. The APOKYN (apomorphine) label is for an injected Parkinson’s medicine, not approval of an ED combination; Mendoxa’s compounded tablet is not FDA-approved. See ED and nitrates.
Mendoxa ED plans and prices
The Mendoxa ED tablet is a compounded rapid-dissolve tablet with sildenafil (the active ingredient in Viagra), tadalafil (the active ingredient in Cialis) and apomorphine (APOKYN label). It dissolves under the tongue. A licensed clinician decides if it fits you and selects the strength. Compounded medicines are not FDA-approved.
| Tablets per month | 1-month total | Per tablet (1 month) | 3-month total | Per tablet (3 months) |
|---|---|---|---|---|
| 6 tablets / month | $129 | $21.50 | $329 | $18.28 |
| 10 tablets / month | $149 | $14.90 | $379 | $12.63 |
| 20 tablets / month | $179 | $8.95 | $449 | $7.48 |
The 3-month total covers three months at the monthly tablet quantity shown.
If prescribed · Cancel anytime · Available in 49 states (not California). Prices from the Mendoxa intake at try.mendoxa.co/f/ed on Oct 21, 2026. The intake always shows the current price.
FAQ
Can erectile dysfunction be cured?
Some causes can improve, but a permanent cure cannot be assumed. NIDDK recommends addressing the cause when possible; symptom treatment may still be needed.
Is erectile dysfunction permanent?
Not necessarily: a 5-year observational study reported 29% remission among eligible men (Martin 2014). It does not establish your likelihood of recovery or prove that improvement happened without treatment.
Can ED go away on its own?
It may improve, but “remission” does not mean “resolved without treatment.” The Martin study did not test waiting versus care; because ED may indicate another condition, discuss it with a clinician (NIDDK).
Can losing weight reverse ED?
For some men. In a 2-year randomized trial of obese men with ED, 17 of 55 in the weight-loss and exercise group scored 22 or higher on the IIEF erectile score, versus 3 of 55 controls (Esposito, JAMA 2004). The trial excluded men with diabetes, hypertension or high cholesterol.
Do Viagra or Cialis fix ED permanently?
The Viagra (sildenafil) label and Cialis (tadalafil) label describe symptom treatment requiring sexual stimulation. They do not establish permanent reversal of the cause; both labels contraindicate use with organic nitrates.
Can ED be reversed after prostate surgery?
Recovery is possible but varies. A 2009 analysis reported 58% recovery across 22 selected studies in men without pre-surgery ED, with at least 1 year of follow-up (Tal 2009). That is not a personal prognosis; ask your urologist about your operation and whether recovery is being measured with or without treatment.
Ready to see if the Mendoxa ED tablet fits you?
From $129/month if prescribed · Cancel anytime · Available in 49 states (not California)
How we wrote this
Written by the Mendoxa editorial team · Sources: DailyMed/FDA. Medical facts on this page come from the FDA-approved labels on DailyMed and Drugs@FDA; each drug name links to its label. Cause and outlook information also comes from the linked NIH/NIDDK pages and PubMed studies. We distinguish symptom treatment, study-defined remission and recovery after surgery; these outcomes are not interchangeable. Study populations and follow-up periods appear beside the results, and no study percentage is a prediction for you.
Updated Oct 21, 2026. This page is general information, not medical advice. A licensed clinician decides what fits you.
References
- DailyMed: VIAGRA (sildenafil citrate) tablet, film coated, label revised 12/2017. Accessed Oct 21, 2026.
- DailyMed: CIALIS (tadalafil) tablet, film coated, label revised 3/2026. Accessed Oct 21, 2026.
- DailyMed: APOKYN (apomorphine hydrochloride) injection, label revised 6/2022. Accessed Oct 21, 2026.
- FDA (Drugs@FDA): VIAGRA (sildenafil) prescribing information, NDA 020895. Accessed Oct 21, 2026.
- FDA (Drugs@FDA): CIALIS (tadalafil) prescribing information, NDA 021368. Accessed Oct 21, 2026.
- FDA: Compounding and the FDA, questions and answers. Accessed Oct 21, 2026.
- NIDDK (NIH): Erectile Dysfunction (ED), last reviewed October 2024. Accessed Oct 21, 2026.
- NIDDK (NIH): Symptoms & Causes of Erectile Dysfunction, last reviewed October 2024. Accessed Oct 21, 2026.
- NIDDK (NIH): Treatment for Erectile Dysfunction, last reviewed October 2024. Accessed Oct 21, 2026.
- NIDDK (NIH): Diabetes, Sexual, & Bladder Problems. Accessed Oct 21, 2026.
- Esposito K, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004;291(24):2978-84 (PubMed 15213209). Accessed Oct 21, 2026.
- Martin SA, et al. Predictors of sexual dysfunction incidence and remission in men. J Sex Med 2014;11(5):1136-47 (PubMed 24548342). Accessed Oct 21, 2026.
- Tal R, et al. Erectile function recovery rate after radical prostatectomy: a meta-analysis. J Sex Med 2009;6(9):2538-46 (PubMed 19515209). Accessed Oct 21, 2026.
- Snyder PJ, et al. Effects of testosterone treatment in older men. N Engl J Med 2016;374(7):611-24 (PubMed 26886521). Accessed Oct 21, 2026.
- DailyMed: AndroGel (testosterone) gel, ingredient reference only; the trial result is from Snyder 2016. Accessed Oct 21, 2026.
- Mendoxa ED care (product, format, max 1 dose per 24 hours). Accessed Oct 21, 2026.
- Mendoxa ED intake: plan prices (term_options). Accessed Oct 21, 2026.
About Mendoxa
Mendoxa (mendoxa.co) is a US telehealth brand. Independent licensed providers (licensed clinicians in the LocumTele network) review each online visit, and prescriptions are filled by Rush Pharmacy, a licensed US pharmacy. Available in 49 states (not California).
- Prescription required. A licensed clinician reviews every visit and can say no. A prescription is not automatic.
- A compounded medicine is not an FDA-approved finished product (FDA compounding Q&A).
- Plans: 1 month or 3 months, from $129. If prescribed · Cancel anytime · Available in 49 states (not California).
Compounded medication prescribed only if a licensed U.S. clinician decides it is appropriate. Not FDA-approved as a finished product. Not available in California. This site is not for emergencies. Call 911 if you need urgent care.